吴远根教授
发布时间:2017-06-02 浏览次数:

吴远根,博士,教授,贵州省“千”层次创新人才

2014年获得上海交通大学环境工程专业博士学位,2015年入选贵州省高层次创新人才“千”层次计划,目前在应用生物技术专业招收硕士研究生。近年来主要研究方向是利用SELEX 技术,筛选发酵原料及产品中有毒有害污染物(如重金属、农药、生物毒素、抗生素、致病菌等)的核酸识别配体,并以贵金属和无机纳米材料等作为信号载体分子,建立基于功能性核酸技术的食品质量安全快速检测新技术和产品。已在Chemical Communications、Nanoscale、Sensors and Actuators B: Chemical、Analyst 等知名杂志上发表SCI论文20余篇,署名论文被SCI引用380 余次,任多个国际期刊审稿专家。

主持的科研项目:

[1]国家自然科学基金:基于核酸适配体的百草枯残留快速检测与去除研究(21565009,2016年—2019年)

[2]国家自然科学基金:核酸生物传感器应用于水体中镉和砷的检测研究(21205020,2013年—2015年)

[3]贵州省科学技术基金重点项目:核酸适配体应用于农产品中农药残留检测研究(黔科合基础[2016]1403号,2016年—2020 年)

[4]贵州省科技厅科技合作计划:核酸适配体应用于乳制品中抗生素残留检测研究(黔科LH字[2015]7682号,2015年—2017年)

[5]贵州省教育厅招标项目:核酸适配体应用于白酒塑化剂残留快速检测研究(黔教合KY 字[2014]261号,2014年—2017年)

代表性论文(*通讯作者):

[1]Huayun Chen, Yuangen Wu*, Wenping Yang, Shenshan Zhang, Shuyi Qiu, Pei Zhou. Ultrasensitive and selective detection of isocarbophos pesticide based on target and random ssDNA triggered aggregation of hemin in polar organic solutions, Sensors and Actuators B: Chemical, 2017, 243, 445-453. (SCI,IF = 4.758)

[2]Huayun Chen, Yuangen Wu*, Wenping Yang, Jing Zhao. Colorimetric determination of isocarbophos based on the enhanced peroxidase-like activity of hemin, Chinese Journal of Analytical Chemistry, 2017, 45(4), 508-513. (SCI,IF = 0.554)

[3]Yuangen Wu, Shenshan Zhan, Lurong Xu, Weiwei Shi, Tao Xi, Xuejia Zhan, Pei Zhou*. A simple and label-free sensor for mercury(II) detection in aqueous solution by malachite green based on a resonance scattering spectral assay, Chemical Communications, 2011, 47(21), 6027-6029. (SCI,IF = 6.834)

[4]Yuangen Wu, Shenshan Zhan, Faze Wang, Lan He, Wenting Zhi, Pei Zhou*. Cationic polymers and aptamers mediated aggregation of gold nanoparticles for the colorimetric detection of arsenic(III) in aqueous solution, Chemical Communications, 2012, 48(37), 4459-4461. (SCI,IF = 6.834)

[5]Yuangen Wu, Shenshan Zhan, Haibo Xing, Lan He, Lurong Xu, Pei Zhou*. Nanoparticles assembled by aptamers and crystal violet for arsenic(III) detection in aqueous solution based on a Resonance Rayleigh scattering spectral assay, Nanoscale, 2012, 4 (21), 6841-6849. (SCI,IF = 7.394)

[6]Yuangen Wu, Le Liu, Shenshan Zhan, Faze Wang, Pei Zhou*. Ultrasensitive aptamer biosensor for arsenic(III) detection in aqueous solution based on surfactant-induced aggregation of gold nanoparticles, Analyst, 2012, 137(18), 4171-4178. (SCI,IF = 4.107)

[7]Yuangen Wu, Shenshan Zhan, Lumei Wang, Pei Zhou*. Selection of a DNA aptamer for cadmium detection based on cationic polymer mediated aggregation of gold nanoparticles, Analyst, 2014, 139 (6), 1550-1561. (SCI,IF = 4.107)

[8]Yuangen Wu, Faze Wang, Shenshan Zhan, Le Liu, Yanfang Luo, Pei Zhou*. Regulation of hemin peroxidase catalytic activity by arsenic-binding aptamers for the colorimetric detection of arsenic(III), RSC Advances, 2013,3, 25614-25619. (SCI,IF = 3.840)

[9]Shenshan Zhan, Yuangen Wu, Lumei Wang, Xuejia Zhan, Pei Zhou*. A mini-review on functional nucleic acids-based heavy metal ion detection, Biosensors and Bioelectronics, 2016, 86:353-368. (SCI, IF = 7.467)

授权和申请的专利:

[1]无固定点靶物质的适配体筛选方法(ZL2013100638446)

[2]利用血红素辣根过氧化物酶催化比色检测三价砷的方法(ZL2013100720690)

[3]利用核酸适配体修饰纳米金粒子的三聚氰胺检测方法(ZL2013100769989)

[4]一种基于氯化血红素可控聚集的水胺硫磷便捷检测方法(CN201511001930X)

[5]基于增强氯化血红素催化活性的水胺硫磷比色检测方法(CN201610638425.4)

[6]一种肉眼可辨的水胺硫磷快速比色检测方法(CN201610638495.X)

[7]一种基于氯化血红素催化反应的四环素比色检测方法(CN201610905116.9)